Hearing Loss: Reestablish the Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells 2018

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Hearing Loss: Reestablish the Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells

1MOE Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing 210096, China 2Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China 3Biology Department, University of Massachusetts Amherst, Amherst, MA 01003, USA 4School of Human Communication Disorders, Dalhousie University, 1256 Barrington Street, Halifax,...

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The mammalian cochlea is a highly complex structure which contains several cells, including sensory receptor or hair cells. The main function of the cochlear hair cells is to convert the mechanical vibrations of the sound into electrical signals, then these signals travel to the brain along the auditory nerve. Auditory hair cells in some amphibians, reptiles, fish, and birds can regenerate or r...

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Objective: Generated acoustic trauma by suction and drill may cause sensorineural hearing loss after Tympanomastoid surgery. This study was carried out to determine the relationship of sensorineural hearing loss and chronic otitis media surgery at Ahvaz Jundishapur University of Medical Sciences in Iran. Material and Methods: This prospective study included 386 patients of ch...

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Age-related hearing loss: prevention of threshold declines, cell loss and apoptosis in spiral ganglion neurons

Age-related hearing loss (ARHL) -presbycusis - is the most prevalent neurodegenerative disease and number one communication disorder of our aged population; and affects hundreds of millions of people worldwide. Its prevalence is close to that of cardiovascular disease and arthritis, and can be a precursor to dementia. The auditory perceptual dysfunction is well understood, but knowledge of the ...

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Efr3a Insufficiency Attenuates the Degeneration of Spiral Ganglion Neurons after Hair Cell Loss

Sensorineural hearing loss (SNHL) is caused by an irreversible impairment of cochlear hair cells and subsequent progressive degeneration of spiral ganglion neurons (SGNs). Eighty-five requiring 3 (Efr3) is a plasma membrane protein conserved from yeast to human, and knockout of Efr3a was reported to facilitate the survival of hippocampal newborn neurons in adult mice. Previously, we found Efr3a...

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ژورنال

عنوان ژورنال: Neural Plasticity

سال: 2018

ISSN: 2090-5904,1687-5443

DOI: 10.1155/2018/4759135